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The Vousden team rst identied MDM2 ubiquitinligase inhibitors, 7-nitro-5-deazaavin compounds (HLI98s), through an HTS ofsmall-molecule libraries of 10,000 compounds using an in vitro MDM2 autoubiq-uitination assay [47]. Enlargement in adolescent boyssuggests gynecomastia

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Peroxisomes in hepatocytes are respon-sible for detoxification of ingested alcohol by converting itto acetaldehyde. Therefore, successful treatment of PJI should consider the biofilm statusof the microbes.

They induceremission rapidly but relapses inevitably occurafter variable intervals and gradually the respon-siveness is lost.

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This is believed to increase theactivity of the reproduction system and regulatethe sleep cycle. (1998)Olfactory dysfunction discriminates Alzheimer’s disease frommajor depression. Thecilia are usually up to 200
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